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Acta 1208, 211221

An additional insult or pathogenic factor, often referred to in the literature as the second hit, is required to trigger the progression from simple steatosis to steatohepatitis (MASH), characterized by hepatocellular injury, inflammation, and varying degrees of fibrosis [32]

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In human volunteers and in several animal species, lung aerosol challenge or LPS instillation causes a neutrophil-rich inflammatory response [3], [4], [5]